Sagimet Biosciences announces presentation on FASN inhibitor results

Sagimet Biosciences will present preclinical data at the 7th Obesity and NASH Drug Development Summit on November 28, 2023, in Boston. The presentation details an evaluation of Sagimet’s FASN inhibitor alone or in combination with semaglutide in a preclinical mouse model of nonalcoholic steatohepatitis, using an artificial intelligence based digital pathology platform to assess fibrosis. “We are pleased to report strong preclinical combination results demonstrating that the FASN inhibitor alone, not semaglutide, was responsible for significant reduction of liver fibrosis, a predictor of outcome in NASH,” said Eduardo Bruno Martins, M.D., D.Phil., Sagimet’s Chief Medical Officer. “Building upon the preclinical data presented at AASLD – The Liver Meeting earlier this month, our oral presentation includes transcriptomic profiling analysis which suggests that the FASN inhibitor and semaglutide combination not only has an additive effect but also provides distinct MOAs that could potentially benefit patients living with NASH and dysmetabolic syndrome. We believe that these preclinical data support further clinical evaluation. Our immediate focus remains on advancing denifanstat as a potential monotherapy and we remain on track to report topline results of our FASCINATE-2 Phase 2b clinical trial, including biopsy data, in the first quarter of next year.”