Regeneron says Libtayo demonstrates durable survival benefit at five years

Regeneron Pharmaceuticals announced five-year results from the final pre-specified overall survival analysis of the Phase 3 EMPOWER-Lung 1 trial, which evaluated Libtayo monotherapy versus chemotherapy as a first-line treatment for adults with advanced non-small cell lung cancer with greater than or equal to50% PD-L1 expression and no EGFR, ALK or ROS1 aberrations. The late-breaking results will be presented in an oral session at the IASLC 2024 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer. “The five-year results from EMPOWER-Lung 1 showcase the durable survival benefit and impressive efficacy of first-line Libtayo monotherapy compared to chemotherapy in patients with PD-L1 high, advanced NSCLC, including a direct correlation between survival benefits and PD-L1 expression level,” says Ana Baramidze, MD, PhD, Head of Clinical Research Department at Todua Clinic, Tbilisi, Georgia. “Furthermore, EMPOWER-Lung 1 continues to offer important new data to help doctors increase their understanding of investigational treatment strategies for patients who progress on PD-1 inhibitor monotherapy. For instance, EMPOWER-Lung 1 was one of the few trials to evaluate survival when adding chemotherapy to a PD-1 inhibitor following progression.”