PhenomeX announces publication of study featuring Beacon technology

PhenomeX announced that the Company’s technology was recently featured in a groundbreaking study published in Cell Reports titled “Potent Omicron-neutralizing antibodies isolated from a patient vaccinated six months before Omicron emergence” that has revealed the remarkable efficacy of vaccines in generating potent antibodies against emerging variants at an accelerated rate. The study, conducted by researchers from the La Jolla Institute for Immunology, highlights the pivotal role of scientific collaboration and speed in combating the global health crisis. PhenomeX’s Beacon platform played a crucial role in identifying antibodies from a previously vaccinated patient that exhibited broad activity against multiple Omicron lineages. These monoclonal antibodies also demonstrated exceptional protective efficacy in a mouse model of BA.1 and BA.2 infection. The findings of this study provide compelling evidence that vaccination can elicit antibodies that effectively combat emerging variants such as Omicron. Furthermore, the identification of mAbs exhibiting therapeutic efficacy against BA.1 and BA.2 in a mouse model suggests their potential as a viable treatment option for COVID-19. PhenomeX’s Beacon platform and antibody discovery protocol enabled the isolation of individual B cells, allowing for the screening of secreted antibodies for reactivity to Delta-Spike antigens. The Beacon platform facilitated the rapid identification of potent omicron-neutralizing antibodies six months prior to the emergence of the Omicron variant, showcasing the potential for accelerated vaccine development and therapeutic interventions.