NextCure publishes review article on regulation of tumor immunity

NextCure announced the publication of a review article in the online journal Frontiers in Immunology, highlighting the need for targeting tumor collagen in the extracellular matrix, or ECM, in the tumor microenvironment to enhance anti-tumor immunity. The publication, titled “Regulation of Tumor Immunity and Immunotherapy by the Tumor Collagen Extracellular Matrix,” details how ECM components, specifically collagen, have an active role in immune regulation when dysregulated. Collagen acts as a ligand and interacts with receptors on immune cells to inhibit immune cell subpopulations in the TME. Such interactions disable anti-tumor immune responses and promote tumor growth. In addition, the review highlights how the structural components of the dysregulated ECM create a physical barrier to immune infiltration, further impeding the overall immune response and contributing to tumor progression. The ECM is a major factor in facilitating not only tumor progression, but resistance to various therapeutic treatments, including immunotherapy. The review was published in collaboration with Nordic Bioscience A/S.