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Neurocrine announces Phase 2 SAVITRI met primary efficacy endpoint

Neurocrine (NBIX) Biosciences announced the presentation of new data from the Phase 2 SAVITRI study, which showed statistically significant and clinically meaningful improvement in depression severity at Day 28 and Day 56 with once-daily oral administration of 1 mg osavampator. In recognition of the data presentation, Neurocrine was honored with the 2025 Poster Award at the 38th annual Psych Congress in San Diego. The study met its primary efficacy endpoint, showing a significant reduction in depression severity from baseline to Day 28 compared to placebo, as measured by the Montgomery-Asberg Depression Rating Scale total score. Secondary efficacy endpoints included the change in MADRS total score from baseline to Day 56.

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