Merus (MRUS) announced that the first patient has been dosed in the company’s phase 2 trial evaluating petosemtamab monotherapy in heavily pretreated metastatic colorectal cancer. Petosemtamab is a Biclonics targeting EGFR and LGR5. The phase 2, open-label trial will evaluate the safety and antitumor activity of petosemtamab monotherapy in 3L+ mCRC, post anti-EGFR therapy. To be eligible for enrollment, patients must lack certain mutations as detected in plasma by ctDNA NGS, including KRAS, NRAS.
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