Lisata announce first patient treated in cholangiocarcinoma cohort

Lisata Therapeutics announced treatment of the first patient in the cholangiocarcinoma cohort of the BOLSTER Trial by Dr. Ian Hu, a principal investigator of the study, at The University of Texas MD Anderson Cancer Center in Houston, Texas. The Company had previously announced the first patient in the head and neck squamous cell carcinoma cohort of the study had been treated. The BOLSTER trial is a Phase 2a, double-blind, placebo-controlled, multi-center, randomized study evaluating LSTA1 when added to standard-of-care versus SOC alone in patients with either advanced second-line head and neck squamous cell carcinoma, second-line esophageal squamous cell carcinoma, or first-line cholangiocarcinoma. “We are excited to announce treatment of the first patient in the cholangiocarcinoma cohort of the BOLSTER trial. Cholangiocarcinoma, or bile duct cancer, is a rare and aggressive cancer that often presents with minimal or no symptoms and, therefore, is often diagnosed in its very late stages. Even if diagnosed early, the 5-year survival rate is less than25%. Unfortunately, most patients are diagnosed at a much later stage of disease progression and thus have a 5-year survival prognosis nearing 0%. Our hope is that LSTA1 will demonstrate a marked improvement in the efficacy of standard-of-care therapy for this insidious disease. As we have stated previously, the BOLSTER trial gives us the opportunity to evaluate the potential of LSTA1 in a variety of solid tumor settings in combination with corresponding standards-of-care and will provide direction on possible next steps in development,” stated Kristen Buck, M.D., Executive Vice President of R&D and Chief Medical Officer of Lisata. “With several patients already consented, enrolled, and treated in the study thus far, we are very pleased with its progress to date. We remain committed to developing groundbreaking therapies that can transform the outcomes of individuals facing these life-threatening conditions.”