Lexicon:INPEFA benefited heart failure patients regardless of diabetes duration

Lexicon Pharmaceuticals announced that a post-hoc analysis of Phase 3 data from the SCORED clinical trial demonstrated that INPEFA or sotagliflozin, reduced the risk of major adverse cardiovascular events or MACE, and heart failure HF events across the spectrum of diabetes duration. Researchers noted that HF patients with longer durations of diabetes derived greater benefit from INPEFA, even controlling for similar baseline HbA1c, yet all patients regardless of diabetes duration benefited from the therapy. These findings were presented August 30th at the European Society of Cardiology ESC Congress 2024 in London, United Kingdom and online. Diabetes duration is a well-established significant risk factor for cardiovascular CV disease and its progression. People with longer diabetes duration have a higher CV disease risk. The objective of this analysis of SCORED, one of two pivotal studies that led to FDA approval of INPEFA for heart failure in May 2023, was to evaluate if diabetes duration modifies the efficacy of INPEFA. The primary endpoint was a composite of CV death, HF hospitalization, and urgent heart failure visit events. Secondary endpoints included MACE: CV death, nonfatal heart attack and nonfatal stroke.