Jasper Therapeutics presents data from preclinical briquilimab study

Jasper Therapeutics is presenting preclinical data demonstrating the effect of briquilimab on hematopoietic stem cells at the European Hematology Association Hybrid Congress, being held June 13 – 16, 2024 in Madrid, Spain. The study being presented evaluated the molecular basis of inhibition of the stem cell factor (SCF)/c-Kit signaling pathway via briquilimab and its functional impact on healthy human HSC survival, proliferation, and differentiation. Results from the study demonstrate that blocking of SCF/c-Kit signaling by briquilimab does not cause apoptosis of HSCs, and that HSCs cultured in the presence of briquilimab differentiate directly into CD34- cells with higher c-Kit expression and without increased CD38 expression. “We are pleased to present preclinical data demonstrating the effect of c-Kit inhibition on the HSC compartment,” said Wendy Pang, M.D., Ph.D., Senior Vice President, Research and Translational Medicine of Jasper. “While blocking of SCF/c-Kit signaling by briquilimab does lead to mast cell apoptosis, it is important that it does not have a similar effect on healthy HSCs, and these data indicate that briquilimab instead skews them towards a distinct alternative HSC differentiation pathway. We believe the results of the study align with those observed to-date in clinical trials of anti-c-Kit agents and support the safety profile of briquilimab in mast cell diseases.”