Invivyd’s Pemgarda shows neutralizing activity against SARS-CoV-2 variants

Invivyd announced that new pseudovirus in vitro neutralization data show continued neutralizing activity of PEMGARDATM or pemivibart, and pipeline candidate VYD2311 against dominant SARS-CoV-2 variants KP.3.1.1 and LB.1, and others tested. The Center for Disease Control, CDC, estimates that KP.3.1.1 accounted for 42.2% of circulating variants of SARS-CoV-2 for the last two weeks of August and is the only major variant increasing in proportionality nationally.Invivyd generated these new data as part of its ongoing industrial virology effort, which leverages a consistent, high-quality, independent, third-party pseudoviral system that routinely tests authentic Invivyd-produced pemivibart and is supported by extensive structure-based analytics. KP.3.1.1, LB.1, and other viruses now assessed and confirmed as susceptible to pemivibart contain key mutations prominent in circulating SARS-CoV-2 variants such as Q493E and the S31 deletion that, while outside of the pemivibart binding site, can influence viral antibody evasion. As of September 2024, the primary structure of the pemivibart epitope has remained intact across 99.59% of viral sequences deposited in Global Initiative on Sharing All Influenza Data or GISAID since the original Omicron BA.1 variant. This breadth of continuing pemivibart activity highlights Invivyd’s industry-leading efforts to generate and advance high quality, variation-resistant COVID-19 antibody medicines. “At Invivyd, we combine surveillance, predictive modeling and antibody engineering towards developing antibody medicines designed to demonstrate continued activity in the face of ongoing SARS-CoV-2 evolution,” said Robert Allen, Ph.D., Chief Scientific Officer. “Pemivibart has now demonstrated antiviral activity against thirty-three distinct SARS-CoV-2 variants across more than two years of rapid virus evolution from Omicron BA.2 through to the most common current virus KP.3.1.1 and related tested variants.”