William Blair downgraded Intellia Therapeutics (NTLA) to Market Perform from Outperform after the company announced that it has voluntarily paused enrollment and dosing of its Phase 3 MAGNITUDE and MAGNITUDE-2 studies for ATTR-cardiomyopathy and ATTR-polyneuropathy, respectively, as the company investigates its TTR gene editor nex-z after a patient dosed in the MAGNITUDE study was hospitalized following incidence of abdominal pain and subsequent observation of grade 4 increases in liver enzymes. The firm is downgrading shares based on current uncertainties surrounding the safety of NTLA-2001 and the remainder of patient enrollment for the MAGNITUDE studies, the analyst tells investors.
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