Indaptus Therapeutics previews presentation of mechanism of action data

Indaptus Therapeutics announces that Dr. Michael Newman, Founder and Chief Scientific Officer of Indaptus, will present a poster at the 2024 Annual Meeting of the American Association for Cancer Research in San Diego on Wednesday morning, April 10th. An abstract of the data to be presented has been published online in the AACR Journal, Cancer Research. The data confirm and significantly extend the proposed mechanism of action of the Company’s proprietary platform technology of attenuated and killed, non-pathogenic bacteria containing multiple immune receptor agonists for pulsed anti-tumor immunotherapy. Dr. Newman commented, “These new data demonstrate that our patented single agent Decoy bacteria were able to induce or activate multiple human innate and adaptive immune cell types involved in anti-tumor responses, including M1 macrophages, natural killer cells, dendritic cells, Th1 CD4, and CD8 T cells. The activity was associated with induction of human tumor cell killing by Decoy bacteria in the presence of immune cells. Potentially unacceptable toxicity from this breadth of immune activation is avoided by using systemically administered killed bacteria as a delivery vehicle. Bacteria have been shown to be cleared very quickly by immune organs, and our clinical data have demonstrated broad immune activation with clearance of the product within approximately two hours, validating our ‘pulse-prime’ hypothesis. This burst of immune system activation exhibited by Decoy has the potential to reduce the chance for toxicities associated with continuous drug exposure.”