Illumina releases its novel 5-base solution

Illumina (ILMN) announced the release of its novel 5-base solution, enabling researchers to pursue broader biological questions with accuracy and ease. The 5-base solution marks a major advancement in scalable multiomic analysis, enabling simultaneous detection of both genomic variants and DNA methylation from a single sample, in a streamlined, cost-effective workflow. Powered by Illumina’s proprietary 5-base chemistry and custom DRAGEN algorithms, the solution delivers high-resolution insights into both the methylome and genome while reducing complexity and cost. This powerful workflow can help researchers uncover disease mechanisms, detect and discover biomarkers for cancer and genetic disease, study disease progression, identify drug targets, and advance precision medicine. Unlike conventional methylation conversion technologies, Illumina’s proprietary conversion chemistry selectively converts methylated cytosine to thymine. This selective conversion of methylated cytosines preserves genomic complexity and variant information in the sequencing library, generating maximum biological insights in each run. London Health Sciences Centre Research Institute’s research chair in Clinical Genomics and Epigenomics, Bekim Sadikovic, is one of over 50 early testers applying the 5-base solution to their multiomic research questions. In addition to its new 5-base solution, Illumina is showcasing the new Illumina Protein Prep product along with its full range of multiomics technology this week at ASHG. Those interested in the ASHG talks but unable to attend the presentation can preregister for the on-demand webinar here.