Eloxx Pharmaceuticals reports drug response in all patients treated with ELX-02

Eloxx Pharmaceuticals reported additional positive results from its proof-of-concept Phase 2 open-label clinical trial of ELX-02 for the treatment of Alport syndrome after eight weeks of treatment. Electron microscopy assessment of kidney biopsies demonstrated an improvement in foot process effacement in all three treated patients. These results are consistent with the disease modifying effect of restoration of COL4A4 protein with ELX-02 and with previously reported data from preclinical studies. “These are profound results. The improvement in podocyte foot process effacement in all three patients treated confirms the disease modifying potential of ELX-02. Combined with the reduction of proteinuria achieved in one patient, these data strengthen our confidence in ELX-02’s potential to treat Alport syndrome patients with nonsense mutations,” said Sumit Aggarwal, President and Chief Executive Officer of Eloxx. “We look forward to initiating a pivotal trial as we believe ELX-02 has the potential to be transformational in this underserved patient population.”