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Edgewise Therapeutics announces intial dosing in EDG-7500 trial

Edgewise Therapeutics announced initial dosing in a Phase 1 trial of EDG-7500. EDG-7500 is a oral, selective, cardiac sarcomere modulator, specifically designed to slow early contraction velocity and address impaired cardiac relaxation associated with HCM and other diseases of diastolic dysfunction. The Phase 1 trial will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of EDG-7500 in healthy adults. The company is also planning to begin a Phase 1b study of EDG-7500 in individuals with obstructive HCM in the first half of 2024.

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