Corbus Pharmaceuticals announce publication of CRB-913

Corbus Pharmaceuticals announced results of a pre-clinical study on its CRB-913 cannabinoid type-1 receptor inverse agonist have been selected for oral presentation at the 11th annual Obesity Journal Symposium, held during the 2023 Obesity Week Conference in Dallas, Texas October 14-17, 2023. In addition, the work has also been selected as a late breaking poster. “These data point to the potential of CRB-913, both as a monotherapy in combination with incretin therapies,” said Yuval Cohen, Ph.D., Chief Executive Officer of Corbus. “We look forward to this differentiated anti-obesity drug candidate advancing to the clinic and to selecting the best partnership path forward to accelerate that process.” The pre-clinical study evaluated the anti-obesity effects of CRB-913, a peripherally restricted inverse agonist as monotherapy and in combination with incretin analogs in a diet induced-obesity mouse model. CRB-913 demonstrated markedly enhanced plasma exposure and markedly reduced brain levels compared to the first generation CB1 inverse agonist rimonabant. CRB-913 monotherapy yielded dose-dependent decrease in body weight in DIO mice that was further enhanced in combination with tirzepatide, semaglutide, or liraglutide. Concomitantly, improvements were observed in body fat content, leptinemia, insulin resistance, liver triglycerides, liver fat deposits and liver histology. All changes were statistically significant. CRB-913 did not induce any loss of lean mass. Investigators concluded that CRB-913, in combination with incretin analogs, could potentially deliver meaningful improvements in obesity and related conditions.