Centessa announces dosing of first subject in PRESent-2 study of SerpinPC

Centessa Pharmaceuticals announced the dosing of the first subject in its registrational PRESent-2 study of SerpinPC for the treatment of hemophilia B without inhibitors. The dosing phase of PRESent-2 follows a minimum 12-week observation period during which prospective baseline data of the subject’s disease status under their current therapy are collected to support regulatory review of the benefit and risk profile of SerpinPC. “There remains a significant global need for new treatment options for persons with hemophilia B,” said Antoine Yver MD MSc, Chairman of Development of Centessa. “Based on encouraging clinical data from our ongoing Phase 2a study, we believe SerpinPC has the potential to be a first-in-class subcutaneously administered therapy with a differentiated safety profile for persons with hemophilia B, subject to regulatory review and approval. We are excited to be evaluating the potential of SerpinPC’s novel mechanism of action in the registrational PRESent-2 study. We expect to enroll and dose additional patients across our clinical trial sites and advance toward the interim analysis planned when 36 subjects reach 12 weeks on treatment in Part 1 of the study.”