Castle Biosciences publishes study on DecisionDx in SCC patients

The company “announced the publication of a study in the International Journal of Radiation Oncology * Biology * Physics demonstrating the ability of the DecisionDx-SCC test to identify high-risk cutaneous squamous cell carcinoma, or SCC, patients at the highest risk of metastasis who will benefit the most from ART to reduce metastatic disease progression, as well as high-risk patients who the test identified as having a lower risk of metastasis who may consider deferring treatment. These results demonstrate the impact of the test in guiding decision-making for recommending ART. The DecisionDx-SCC test identified patients projected to receive the greatest benefit from ART to reduce metastatic disease progression. Patients with a Class 2B (highest metastatic risk) test result who were treated with ART had 50% higher MFS rates, on average, than Class 2B patients who did not receive ART at five years post-diagnosis. Class 2B patients who received ART showed a significant deceleration in disease progression compared to Class 2B patients who did not receive ART. For patients with a DecisionDx-SCC Class 2B test result who were not treated with ART, there was a peak rate of metastasis around two years; Class 2B, ART-treated patients had nearly five times longer projected time to metastasis.”