Caribou Biosciences (CRBU) announced positive results from its ongoing ANTLER phase 1 clinical trial evaluating vispacabtagene regedleucel, vispa-cel, an allogeneic anti-CD19 CAR-T cell therapy, in patients with relapsed or refractory B cell non-Hodgkin lymphoma. Data demonstrate efficacy and durability of vispa-cel, an allogeneic anti-CD19 CAR-T cell therapy, are on par with autologous CAR-T cell therapies in the confirmatory cohort and with longer-term follow-up on patients who received optimized vispa-cel: 82% ORR, 64% CR rate, 51% PFS at 12 months in patients prospectively enrolled in partial HLA matching confirmatory cohort, 86% ORR, 63% CR rate, 53% PFS at 12 months in patients who received vispa-cel with an optimized profile
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