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Calidi announces issuance of U.S. patent on SuperNova tech platform

Calidi Biotherapeutics announced the issuance of a new patent for the company’s SuperNova technology, strengthening its intellectual property portfolio and positioning Calidi to advance its CLD-201 program into the clinic. The United States Patent and Trademark Office has issued U.S. Patent No. 12,036,278 titled, “Smallpox Vaccine for Cancer Treatment,” directed to Calidi’s SuperNova platform composed of adipose-derived mesenchymal stem cells loaded with oncolytic vaccinia virus. The patent covers methods and compositions related to immunotherapy of cancer, specifically compositions combining a smallpox vaccine with stem cells, selected from among 19 different stem cell types and their combinations. Importantly, this patent broadens previously allowed claims to include 21 smallpox vaccine virus strains. Extensive Calidi research has shown the potential ability of the SuperNova platform to shield the viral payload from the immune system, supporting efficient delivery to tumor sites and effectively potentiating oncolytic viruses’ therapeutic efficacy.

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