Biogen to present new data on Alzheimer’s disease portfolio

Biogen will present new data from its Alzheimer’s disease portfolio at the upcoming Clinical Trials on Alzheimer’s Disease meeting taking place October 24-27 in Boston, Mass. The presentations will advance the understanding of Alzheimer’s disease with data on different treatment approaches, predictive analysis of disease progression, and clinical meaningfulness of amyloid removal for patients and their caregivers. Biogen presentations will include data from the multiple ascending dose and long-term extension phases of the Phase 1b study evaluating exploratory clinical outcomes associated with tau reduction in patients with early Alzheimer’s disease. New data on LEQEMBI, developed in collaboration with Eisai Co., Ltd., will be presented with discussion of preliminary data on a subcutaneous formulation, as well as biomarker assessments from Clarity AD, including the role of tau as a predictive biomarker, and the implications of targeting protofibrils. Select presentations from CTAD will be available on Biogen.com at the time of the conference presentation. Key Presentations Include: Late-breaking oral presentation: Exploratory clinical outcomes from BIIB080 Phase 1b multiple ascending dose and long-term extension study in mild Alzheimer’s disease: Wednesday, October 25, 10:50 a.m. Late-breaking symposium 4: Lecanemab for Early Alzheimer’s Disease: Long-Term Outcomes, Predictive Biomarkers and Novel Subcutaneous Administration: Wednesday, October 25, 5:25 p.m. The presentation will include the latest data from the CLARITY AD optional tau PET longitudinal sub-study. A post-hoc analysis of the low and intermediate + high-tau subgroups, including the low-tau subgroup specifically studied in the Phase 3 core study, and data from the open-label extension study will be included in the presentation. An update on the investigational subcutaneous formulation with the effect on amyloid as measured by amyloid PET and interim safety, will also be provided. Late-breaking oral presentations: Pooled ENGAGE/EMERGE Integrated Placebo-controlled Period and Long-Term Extension Topline Results: Slower Clinical Progression at Week 134 in Aducanumab-treated Patients that Became Amyloid PET Negative at Week 78: Wednesday, October 25, 8:30 a.m. Aducanumab Phase 3b EMBARK Study Interim Analysis: Topline Safety Results: Friday, October 27, 2:00 p.m. Oral presentation: Precision medicine analysis of heterogeneity in individual-level treatment response to beta-amyloid removal in early Alzheimer’s disease: Thursday, October 26, 4:35 p.m.