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Avalo Therapeutics downgraded to Perform from Outperform at Oppenheimer

Oppenheimer downgraded Avalo Therapeutics to Perform from Outperform. With the Phase 2 PEAK trial of AVTX-002 in non-eosinophilic asthma having missed its primary endpoint of asthma-related clinical events versus placebo and cash resources remaining limited, the firm is moving to the sidelines as the company evaluates its next steps. Nonetheless, the drug having reduced such clinical events by about 50% in the sub-group with elevated baseline levels of LIGHT per Oppenheimer’s discussion with management provides an “encouraging clinical signal” as well as sets the stage for potential future development to incorporate a biomarker-based approach, the firm adds.

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