Atossa announces last patient, last dose in Phase 2 Karisma-Endoxifen trial

Atossa Therapeutics announced that the last patient in the Company’s Karisma-Endoxifen clinical trial received their final dose of study medication. Atossa is a clinical stage biopharmaceutical company developing innovative medicines in areas of significant unmet medical need in oncology with a focus on breast cancer. The Karisma-Endoxifen study, which fully enrolled in November 2023, is a 240-person Phase 2 clinical trial investigating (Z)-endoxifen in premenopausal women with measurable mammographic breast density. “Completing dosing of the final patient in the Karisma-Endoxifen study is an important milestone for Atossa and our robust (Z)-endoxifen development program, which includes five ongoing Phase 2 studies,” said Steven Quay, M.D., Ph.D., Atossa’s President and Chief Executive Officer. “We look forward to seeing the breast density reduction data in the coming months and sharing it with regulatory authorities as it will allow us to further progress plans for a potential Phase 3, registrational study.”