Atossa announces full enrollment of Z-endoxifen arm of I-SPY 2 trial

Atossa Therapeutics announced that the (Z)-endoxifen arm of the ongoing Phase 2 I-SPY 2 clinical trial has fully enrolled. In the study, (Z)-endoxifen, Atossa’s proprietary Selective Estrogen Receptor Modulator, is being evaluated as a neoadjuvant treatment for newly diagnosed estrogen receptor-positive invasive breast cancer. “We are excited that the (Z)-endoxifen arm of the I-SPY 2 study has fully enrolled and look forward to seeing data from this study in the second half of 2024,” said Steven Quay, MD, PhD, Atossa’s President and Chief Executive Officer. “Estrogen receptor positive breast cancer accounts for over 80% of all breast cancer diagnoses and unfortunately, the current neoadjuvant treatment options for these patients are sub-optimal. Treatment with (Z)-endoxifen has the potential to down-stage the tumor, improve tumor resectability and reduce the incidence of breast cancer recurrence, all while demonstrating a far superior safety and tolerability profile compared to aromatase inhibitors and systemic chemotherapy. This would transform the treatment paradigm for the hundreds of thousands of women diagnosed with ER-positive breast cancer every year.”