Ascendis: eGFR improved in TransCon PTH-treated adults with hypoparathyroidism

Ascendis Pharma announced new post hoc analysis showing adults with hypoparathyroidism treated with TransCon PTH demonstrated substantial improvement in estimated glomerular filtration rate, eGFR , suggesting improved kidney function. TransCon PTH, palopegteriparatid, is an investigational prodrug of parath yroid hormone PTH 1-34 administered once daily designed to provide sustained release of active PTH within the physiological range for 24 hours per day in adult patients with hypoparathyroidism. “Chronic kidney disease is one of the most consequential complications of chronic hypoparathyroidism and its treatment with conventional therapy. Diminished kidney function is associated with its own set of complications, including hypertension, edema, and weakness,” said Dr. Aliya Khan, M.D., Clinical Professor of Medicine at McMaster University and Director of the Calcium Disorders Clinic at McMaster University Medical Center. “The observations in the post hoc analysis of the PaTHway Trial, suggesting that treatment with TransCon PTH reverses impaired kidney function in patients with hypoparathyroidism, further substantiating the promise for a major improvement in treatment opportunities and outcomes for people living with hypoparathyroidism.””We will continue to study this important data and topic, which suggests the potential of TransCon PTH to address physician and patient concerns about soft-tissue calcifications and decreased kidney function associated with conventional therapy,” said Aimee Shu, M.D., Vice President, Clinical Development, Endocrine & Rare Diseases at Ascendis Pharma. “In addition to reducing risk for patients, this could also help significantly reduce the healthcare burden associated with hypoparathyroidism. We look forward to presenting detailed results at an upcoming medical conference.””We will continue to study this important data and topic, which suggests the potential of TransCon PTH to address physician and patient concerns about soft-tissue calcifications and decreased kidney function associated with conventional therapy,” said Aimee Shu, M.D., Vice President, Clinical Development, Endocrine & Rare Diseases at Ascendis Pharma. “In addition to reducing risk for patients, this could also help significantly reduce the healthcare burden associated with hypoparathyroidism. We look forward to presenting detailed results at an upcoming medical conference.”