Ardelyx shares data on IBSRELA via oral presentation, posters

Ardelyx announced that they will share positive data on IBSRELA via an oral presentation and two posters at the American College of Gastroenterology annual meeting, being held October 20 to 25 in Vancouver, Canada. IBSRELA, discovered and developed by Ardelyx, is a first-in-class treatment that is currently approved by the U.S. Food and Drug Administration to treat irritable bowel syndrome with constipation in adults. The oral presentation, titled Tenapanor Treatment Success for IBS-C Symptoms Increases with Duration of Therapy, will share findings from a pooled analysis of the phase 2b and phase 3 T3MPO studies of IBSRELA in adult patients. These studies looked at the effects of the drug on abdominal pain and other IBS-C symptoms. The new post-hoc data presented today evaluate the time to onset of tenapanor effect on bowel function and abdominal symptoms in adult patients with IBS-C. The researchers concluded that these patients experience a relatively quick onset of symptom relief under tenapanor treatment and that weekly response rates continued to increase with treatment duration. The first poster to be presented at the ACG meeting, titled Tenapanor Can Improve Abdominal Symptoms Independent of Changes in Bowel Movement Frequency in Adult Patients with IBS-C, also looks at data from the T3MPO studies. The data showed that tenapanor improved abdominal symptoms regardless of improvement in complete solid bowel movements in adult patients with IBS-C and that improvement in abdominal symptoms without improvement in CSBMs may be a result of tenapanor’s novel mechanism of action that has been shown to reduce both intestinal permeability and visceral hypersensitivity in nonclinical studies. The second poster, Improvement in Bloating and Overall Complete Spontaneous Bowel Movement Response with Tenapanor Treatment: A Post Hoc Analysis of the IBS-C Clinical Studies, analyzes data from the T3MPO studies to assess the relationship between improvement in bloating and overall CSBM response in patients treated with tenapanor. This analysis concluded that patients with tenapanor demonstrated a marked improvement in average weekly bloating score, and that patients who had an overall CSBM response had a greater improvement in bloating than those who did not.