Annovis Bio announces issuance of U.S. patent covering buntanetap

Annovis announced that the United States Patent and Trademark Office has granted the Company a patent with claims covering the use of Annovis Bio’s lead drug candidate, buntanetap, for the prevention and treatment of diseases caused by the disruption in heavy metal homeostasis. U.S. Patent 11,596,621 B2 is titled, "Prevention or Treatment of Disease States Due to Metal Dis-homeostasis Via Administration of Posiphen [buntanetap] to Healthy or Sick Humans" and was issued on March 7, 2023. The patent is expected to confer protection for use of buntanetap and its related analogue molecules for the prevention and treatment of various neurodegenerative diseases associated with metal dis-homeostasis out to early 2040. The ‘621 patent covers the use of buntanetap for maintaining or restoring heavy metal homeostasis as a method of prevention in healthy humans or as a method of treatment in sick humans. Metal dis-homeostasis, particularly iron, is a hallmark of various conditions including neurodegenerative diseases, cardiovascular diseases, cancer, and vital organ dysfunction. The ‘621 patent provides coverage for several aspects of treatment with buntanetap, preventing disease through chronic prophylactic use of buntanetap in healthy humans to maintain iron homeostasis, and use of the drug to restore iron homeostasis in sick humans.