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Amarin announces new in vitro data on eicosapentaenoic acid
The Fly

Amarin announces new in vitro data on eicosapentaenoic acid

Amarin Corporation highlighted new in vitro data supporting the potential mechanistic effects of eicosapentaenoic acid, EPA, in reducing cardiovascular events in at-risk patients presented at the joint ACC.23 together with the World Congress of Cardiology in New Orleans, LA, March 4-6, 2023. The ACC.23/WCC 2023 presentations were as follows: Eicosapentaenoic Acid Modulated Expression of Proteins Linked to Platelet Activation and Thrombosis in Vascular Endothelial Cells during Inflammation. Highlights: This in vitro study suggests potential antithrombotic mechanisms for EPA that may contribute to reduced ischemic events. Importantly, these findings follow data from REDUCE-IT ACS, also presented at ACC.23/WCC, showing bleeding rates were not more frequent with icosapent ethyl than placebo despite extensive use of background antithrombotic therapy. Pharmaceutical Grade Mineral Oil and Corn Oil do not Influence Phospholipid Membrane Oxidation Rates Compared to Omega-3 Fatty Acids In Vitro. Highlights: This in vitro study compared the effects of pharmaceutical grade mineral oil, corn oil, EPA, or DHA on rates of membrane lipid oxidation and found that EPA had potent antioxidant effect in membranes that were sustained over time compared with DHA and that placebo oils had no effects on oxidation even at very high levels. The data showed EPA inhibited membrane oxidation by 89% compared to vehicle after 72 hours, while DHA mildly inhibited oxidation at this time point versus vehicle. Comparing the Effects of Pharmaceutical Grade Mineral Oil, Corn Oil, Eicosapentaenoic Acid and Docosahexaenoic Acid in a Model of Atherosclerosis In Vitro. Highlights: This in vitro study found EPA had potent antioxidant effects in apolipoprotein B particles compared to DHA-containing formulations and that pharmaceutical grade mineral oil and corn oil did not influence LDL oxidation even at supra-pharmacologic levels. At four hours, oxidation increased 15-fold and 57-fold in vehicle-treated small dense LDL and very-low-density lipoprotein, respectively, and was unaffected by mineral oil or corn oil. By contrast, EPA significantly inhibited sdLDL and VLDL oxidation by 75% and 94%, respectively, compared with vehicle. While DHA exhibited antioxidant activity at 2 hours at a level less than EPA, this effect was eliminated by 4 hours.

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