TD Cowen lowered the firm’s price target on Alnylam to $260 from $265 and keeps an Outperform rating on the shares. The firm said its FDA CRL for Onpattro’s NDA for ATTR-CM was driven by APOLLO-B’s small effect size despite a positive AdComm and prior alignment with FDA on endpoints/SAP. While disappointing Onpattro/ATTR-CM did not meaningfully contribute to our thesis, TD Cowen said to investors.
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