Actinium Pharmaceuticals reports Iomab-B Phase 3 SIERRA trial results

Actinium Pharmaceuticals announced that results from the Phase 3 SIERRA trial of Iomab-B in patients with a TP53 mutation have been accepted for oral presentation at the 50th Annual meeting of the European Bone Marrow Transplant Society being held April 14 – 17, 2024, in Glasgow, Scotland. Iomab-B is a targeted radiotherapy conditioning agent comprised of an anti-CD45 monoclonal antibody and Iodine-131 radioisotope payload. The Phase 3 SIERRA trial enrolled 153 patients with active relapsed or refractory acute myeloid leukemia and compared outcomes of patients receiving Iomab-B and a bone marrow transplant to those of patients receiving physician’s choice of care in the control arm. In total, 24% of patients (37/153) in the SIERRA trial had a TP53 mutation, which is associated with poor outcomes, and 27 of the TP53 positive patients received Iomab-B. Iomab-B met the primary endpoint of durable Complete Remission in the SIERRA trial with high-statistical significance and 100% of patients receiving a therapeutic dose of Iomab-B achieved BMT access and engagement.