Actinium Pharmaceuticals announced data presented at Society of Immunotherapy of Cancer Annual Meeting further supporting Actimab-A, the company’s clinical stage targeted radiotherapeutic comprised of the CD33 targeting antibody lintuzumab and the Actinium-225 alpha-particle emitting payload. The poster highlighted Actimab-A’s ability to target and deplete myeloid-derived suppressor cells – MDSCs -, which uniformly express CD33. MDSCs are a cell population of interest as they remodel the tumor environment and promote immune evasion. Actinium believes Actimab-A has the potential to be used in combination with immunotherapy, including immune checkpoint inhibitors, to enhance antitumor immunity via targeted MDSC depletion.
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