AC Immune to regain global rights to crenezumab, semorinemab

AC Immune announced that the Company will regain all global rights to the anti-amyloid beta antibody crenezumab and the anti-Tau antibody semorinemab following termination of the collaboration agreements with Genentech, a member of the Roche Group, and Roche. Both antibodies have been evaluated in clinical studies for Alzheimer’s disease. AC Immune will also regain rights to existing GMP drug-product for clinical testing as well as associated data generated under each of the agreements. AC Immune will carefully review and evaluate available data sets, including the final open label extension results from the Lauriet trial when they become available and are received in full by AC Immune, before decisions are made on potential further development and other opportunities. Dr. Andrea Pfeifer, CEO of AC Immune SA, commented: “AC Immune is highly focused on progressing its three active immunotherapies from its precision medicine pipeline. These product candidates are being developed in ongoing, potentially registrational, Phase 2 clinical trials, including the recently initiated first prevention study in presymptomatic Alzheimer’s disease. This approach, using the patients’ own immune system to slow onset and ultimately prevent neurodegenerative diseases, has the potential to revolutionize how these conditions are addressed. With the recent milestone payment from our partner in the Tau active immunotherapy program, plus the USD50 million financing secured in December, we are well financed into 2026, and able to advance multiple high value development programs.