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Ionis Pharmaceuticals: Strategic Positioning and Growth Potential with Olezarsen’s EU Approval and Promising sHTG Market Prospects

Ionis Pharmaceuticals: Strategic Positioning and Growth Potential with Olezarsen’s EU Approval and Promising sHTG Market Prospects

Mitchell Kapoor, an analyst from H.C. Wainwright, reiterated the Buy rating on Ionis Pharmaceuticals. The associated price target remains the same with $95.00.

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Mitchell Kapoor has given his Buy rating due to a combination of factors that highlight Ionis Pharmaceuticals’ strategic positioning and growth potential. The recent EU approval of Olezarsen, branded as TRYNGOLZA, for familial chylomicronemia syndrome (FCS) is a significant milestone. This approval not only validates the company’s strategy but also serves as a stepping stone to the larger severe hypertriglyceridemia (sHTG) market, which is expected to drive substantial commercial success.
Additionally, the promising results from the CORE/CORE2 studies demonstrate Olezarsen’s efficacy in reducing triglyceride levels and acute pancreatitis events in sHTG patients, reinforcing its potential as a groundbreaking therapy. The anticipated U.S. launch in the second half of 2026 further supports the Buy rating, with regulatory momentum and a rich pipeline of upcoming catalysts, including key presentations and updates, bolstering investor confidence. The valuation, based on a discounted cash flow analysis, suggests a 12-month price target of $95 per share, reflecting the company’s robust prospects and potential upside from its diverse product portfolio.

In another report released on September 15, Leerink Partners also maintained a Buy rating on the stock with a $63.00 price target.

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