TD Cowen analyst Brendan Smith has maintained their neutral stance on GBIO stock, giving a Hold rating on October 25.
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Brendan Smith’s rating is based on Generation Bio’s recent scientific achievements and ongoing strategic shifts. The company has made significant progress with its ctLNP platform, demonstrating effective siRNA delivery in non-human primates without triggering T cell activation, which is a critical step for potential applications in autoimmune diseases. This scientific validation is promising, yet it comes at a time of substantial corporate restructuring.
Generation Bio is actively exploring strategic alternatives, including mergers, partnerships, or asset sales, while also implementing a drastic 90% reduction in its workforce to conserve resources. Although the company has managed to settle a significant lease agreement, resulting in a financial gain, its future growth and platform value depend heavily on the outcomes of these strategic decisions. These factors contribute to the Hold rating, as the company’s direction remains uncertain while it navigates these changes.
In another report released on October 25, TR | OpenAI – 4o also reiterated a Hold rating on the stock with a $6.00 price target.

