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Exelixis’s Zanzalintinib Shows Promise in Phase III Trial, Justifying Buy Rating Despite Safety Concerns

Exelixis’s Zanzalintinib Shows Promise in Phase III Trial, Justifying Buy Rating Despite Safety Concerns

William Blair analyst Andy Hsieh has maintained their bullish stance on EXEL stock, giving a Buy rating today.

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Andy Hsieh has given his Buy rating due to a combination of factors including the promising results from the Phase III STELLAR-303 trial, which demonstrated an improved overall survival rate of 10.9 months for Exelixis’s zanzalintinib in combination with Tecentriq. This marks a significant advancement in the treatment of third-line or later metastatic colorectal cancer, surpassing previous benchmarks set by other treatments.
Despite some concerns about the safety profile, particularly the 60% rate of grade 3 and 4 treatment-related adverse events, the reduction in palmar-plantar erythrodysesthesia syndrome incidence is seen as a positive outcome. These findings suggest that zanzalintinib could offer a viable alternative to existing therapies, supporting the Buy rating for Exelixis’s stock.

In another report released today, Morgan Stanley also maintained a Buy rating on the stock with a $50.00 price target.

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