Tscan Therapeutics, Inc. ((TCRX)) announced an update on their ongoing clinical study.
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Study Overview: TScan Therapeutics, Inc. is conducting a clinical study titled A Controlled Multi-Arm Phase 1 Umbrella Study Evaluating the Safety and Feasibility of T-Cell Receptor Engineered Donor T-Cells Targeting HA1 (TSC-100) or HA2 (TSC-101) in HLA-A0201 Positive Patients Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation. The study aims to assess the safety, feasibility, and preliminary efficacy of TSC-100 and TSC-101 in patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or acute lymphoblastic leukemia (ALL) undergoing stem cell transplantation. This research is significant as it explores innovative treatments for these serious conditions.
Intervention/Treatment: The study tests two experimental drugs, TSC-100 and TSC-101, which are T-cell receptor-engineered donor T-cells. These drugs target specific antigens (HA1 and HA2) in patients, aiming to improve treatment outcomes following stem cell transplantation.
Study Design: This Phase 1 study is interventional, non-randomized, and follows a parallel assignment model. It is open-label, meaning both researchers and participants know which treatment is being administered. The primary purpose is to evaluate treatment efficacy and safety.
Study Timeline: The study began on July 11, 2022, and is currently recruiting participants. The last update was submitted on May 14, 2025. These dates are crucial for tracking the study’s progress and ensuring timely updates for stakeholders.
Market Implications: The progress of this study could impact TScan Therapeutics’ stock performance positively if results show promising efficacy and safety, enhancing investor confidence. In a competitive industry focused on innovative cancer treatments, successful outcomes could position TScan as a leader, potentially influencing market dynamics and investor sentiment.
The study is ongoing, with further details available on the ClinicalTrials portal.
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