Bristol-Myers Squibb Company ((BMY)) announced an update on their ongoing clinical study.
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Study Overview: Bristol-Myers Squibb Company is conducting a study titled A Randomized Phase 2/3 Study of BMS-986504 in Combination With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion. The study aims to evaluate the clinical benefit of BMS-986504, a selective MTA-cooperative inhibitor of PRMT5, combined with pembrolizumab and chemotherapy, compared to a placebo combination, for patients with a specific genetic deletion in metastatic non-small cell lung cancer.
Intervention/Treatment: The study is testing BMS-986504, a drug designed to inhibit PRMT5, in combination with pembrolizumab and standard chemotherapy drugs like cisplatin, carboplatin, pemetrexed, paclitaxel, and nab-paclitaxel. The goal is to determine if this combination offers better outcomes than the placebo group.
Study Design: This interventional study is randomized and follows a parallel assignment model. It involves quadruple masking, meaning that participants, care providers, investigators, and outcomes assessors are blinded to the treatment allocations. The primary purpose of the study is treatment-focused.
Study Timeline: The study began on July 3, 2025, and the latest update was submitted on October 10, 2025. These dates are crucial as they indicate the study’s progression and the timeliness of data collection and analysis.
Market Implications: The ongoing study could significantly impact Bristol-Myers Squibb’s stock performance, especially if the results show a substantial benefit of BMS-986504 over the placebo. Positive outcomes could enhance investor sentiment and position BMY favorably against competitors in the oncology market.
Closing Sentence: The study is currently recruiting, and further details are available on the ClinicalTrials portal.