BridgeBio (BBIO) Pharma announced positive topline results from CALIBRATE, its global Phase 3 study of encaleret in autosomal dominant hypocalcemia type 1. CALIBRATE was designed to study the efficacy and safety of encaleret, an investigational, orally-administered, negative allosteric modulator of the calcium-sensing receptor. The primary endpoint, defined as the proportion of participants randomized to receive encaleret achieving both serum calcium and urine calcium in the respective target ranges, was achieved by 76% of encaleret-treated participants compared to 4% for these same participants while on conventional therapy. Encaleret was well-tolerated with no discontinuations related to study drug
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