4D Molecular presents interim data from Phase 1/2 PRISM trial

4D Molecular Therapeutics announced positive interim clinical data from the Phase 1 Dose Exploration stage of the 4D-150 Phase 1/2 PRISM clinical trial for wet age-related macular degeneration. 4D-150, a novel genetic medicine that utilizes 4DMT’s evolved and customized R100 vector for intravitreal delivery to the retina, was well- tolerated at all doses. All doses demonstrated clinical activity, including a reduction in anti-VEGF injection burden, stable or improved retinal edema and thickness, and stable visual acuity. A dose response was demonstrated in favor of the high dose 3E10 vg/eye. Interim data from the study will be presented today in an oral presentation titled, "Interim results for the Phase 1/2 PRISM Trial evaluating 4D-150, a dual-transgene intravitreal genetic medicine in individuals with neovascular age-related macular degeneration," at the 2023 Association for Research in Vision and Ophthalmology Annual Meeting in New Orleans, LA. "These clinical data on 4D-150 represent another important milestone for patients with wet AMD and for 4DMT," said David Kirn, M.D., Co-founder and Chief Executive Officer of 4DMT. "We believe these results further validate the potential of our intravitreal R100 vector, for the safe delivery of effective transgene payloads at relatively low doses, and our Therapeutic Vector Evolution platform. These promising interim clinical data and excellent progress on Phase 2 enrollment further demonstrate the power of our product design and development engine."