BeOne Medicines ((ONC)) announced an update on their ongoing clinical study.
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BeOne Medicines (ONC) is conducting a groundbreaking Phase 1a/1b study titled ‘A Phase 1a/1b Study of BG-68501, a Selective CDK2 Inhibitor, in Participants With Advanced Solid Tumors.’ The study aims to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-68501 in patients with advanced solid tumors. This research is significant as it seeks to identify a recommended dose for expansion, potentially leading to new treatment options for various cancers.
The study tests BG-68501, a cyclin-dependent kinase-2 inhibitor, both as a monotherapy and in combination with fulvestrant and BGB-43395. These interventions aim to treat advanced, nonresectable, or metastatic solid tumors, including hormone receptor-positive breast cancer.
The study follows a non-randomized, sequential intervention model with no masking, focusing primarily on treatment. It is designed to escalate doses and expand safety evaluations, assessing the drug’s effects both alone and in combination with other treatments.
Key dates for the study include its start on February 5, 2024, with the latest update submitted on September 19, 2025. These dates are crucial as they mark the progression and current status of the trial, indicating ongoing recruitment and data collection.
This clinical update could positively impact BeOne Medicines’ stock performance by enhancing investor confidence in the company’s innovative approach to cancer treatment. The study’s progress may also influence the competitive landscape, as successful outcomes could position BeOne Medicines as a leader in oncology therapeutics.
The study is ongoing, with further details available on the ClinicalTrials portal.